Abstract
The effect of mitochondria-targeted antioxidant 10-(6'-plastoquinonyl) decyltriphenylphosphonium bromide (SkQ1) and its fragment dodecyltriphenylphosphonium (C12TPP), weak uncouplers of respiration and oxidative phosphorylation, was studied using a mouse model of carrageenan-induced acute inflammation in the subcutaneous air pouch. In our model, SkQ1 demonstrated a strong anti-inflammatory effect that manifested in a decrease in the absolute number of inflammatory cells, mainly neutrophils, and their relative number in parallel with an increase in macrophages and mast cell content in the inflammatory exudate. The concentration of proinflammatory cytokine IL-6 in the exudate also tended to decrease. C12TPP produced no significant effect on the inflammation process.
Keywords:
C12TPP; SkQ1; acute inflammation; carrageenan; mitochondria-targeted antioxidants.
MeSH terms
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Animals
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Anti-Inflammatory Agents / pharmacology*
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Antioxidants / pharmacology*
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Carrageenan
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Cell Count
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Cell Respiration / drug effects
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Drug Eruptions / immunology
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Drug Eruptions / pathology
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Drug Eruptions / prevention & control*
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Inflammation
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Interleukin-6 / biosynthesis
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Interleukin-6 / immunology
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Macrophages / drug effects
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Macrophages / immunology
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Male
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Mast Cells / drug effects
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Mast Cells / immunology
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Mice
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Mice, Inbred C57BL
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Mitochondria / drug effects
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Mitochondria / metabolism
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Neutrophils / drug effects
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Neutrophils / immunology
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Organophosphorus Compounds / pharmacology*
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Oxidative Phosphorylation / drug effects
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Plastoquinone / analogs & derivatives*
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Plastoquinone / pharmacology
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Skin / drug effects
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Skin / immunology
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Skin / pathology
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Uncoupling Agents / pharmacology*
Substances
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10-(6'-plastoquinonyl)decyltriphenylphosphonium
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Anti-Inflammatory Agents
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Antioxidants
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Interleukin-6
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Organophosphorus Compounds
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Uncoupling Agents
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interleukin-6, mouse
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dodecyltriphenylphosphonium
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Carrageenan
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Plastoquinone