Neuronal Polarity: MAP2 Shifts Secretory Vesicles into High Gear for Long-Haul Transport down the Axon

Luís F Ribeiro; Joris de Wit

doi:10.1016/j.neuron.2017.04.002

Neuronal Polarity: MAP2 Shifts Secretory Vesicles into High Gear for Long-Haul Transport down the Axon

Neuron. 2017 Apr 19;94(2):223-225. doi: 10.1016/j.neuron.2017.04.002.

Authors

Luís F Ribeiro¹, Joris de Wit²

Affiliations

¹ VIB Center for Brain & Disease Research, Herestraat 49, 3000 Leuven, Belgium; Department of Neurosciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
² VIB Center for Brain & Disease Research, Herestraat 49, 3000 Leuven, Belgium; Department of Neurosciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address: joris.dewit@kuleuven.vib.be.

PMID: 28426954
DOI: 10.1016/j.neuron.2017.04.002

Abstract

Accurate control of polarized cargo trafficking is essential for neuronal function. In this issue of Neuron, Gumy et al. (2017) show that MAP2 defines a pre-axonal filtering zone and controls axonal cargo transport by influencing the activities of distinct kinesin motors.

Publication types

Review

MeSH terms

Animals
Axonal Transport / physiology*
Axons / metabolism*
Cell Polarity / physiology*
Humans
Microtubules / metabolism*
Neurons / metabolism*
Secretory Vesicles / metabolism*