Cell-Intrinsic Defense at the Epithelial Border Wall: Salmonella Pays the Price

Sky W Brubaker; Denise M Monack

doi:10.1016/j.immuni.2017.03.021

Cell-Intrinsic Defense at the Epithelial Border Wall: Salmonella Pays the Price

Immunity. 2017 Apr 18;46(4):522-524. doi: 10.1016/j.immuni.2017.03.021.

Authors

Sky W Brubaker¹, Denise M Monack²

Affiliations

¹ Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA.
² Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: dmonack@stanford.edu.

PMID: 28423331
DOI: 10.1016/j.immuni.2017.03.021

Abstract

Within the gut, Salmonella-infected enterocytes are expelled into the lumen, limiting pathogen replication. In this issue of Immunity, Rauch et al. (2017) expand our understanding of this cell-intrinsic response by characterizing the genetic determinants that control the expulsion and death of epithelial cells.

Publication types

Comment

MeSH terms

Enterocytes / immunology
Epithelial Cells
Immunity
Salmonella / immunology*
Salmonella Infections / immunology*