Orbicularisine: A Spiro-Indolothiazine Isolated from Gills of the Tropical Bivalve Codakia orbicularis

J Nat Prod. 2017 May 26;80(5):1693-1696. doi: 10.1021/acs.jnatprod.7b00149. Epub 2017 Apr 19.

Abstract

A novel spiro-indolofuranone fused to a thiazine skeleton, orbicularisine (1), was isolated from gills of the mollusk Codakia orbicularis. The isolation and structure elucidation using spectroscopic evidence including mass and NMR spectroscopy are described. The final structure of 1 was supported by key HMBC correlation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bivalvia / chemistry*
  • Gills / chemistry*
  • Indolizines / chemistry
  • Indolizines / isolation & purification*
  • Indolizines / metabolism
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Spiro Compounds / chemistry
  • Spiro Compounds / isolation & purification*
  • Spiro Compounds / metabolism

Substances

  • Indolizines
  • Spiro Compounds
  • orbicularisine