Clinical Toxicity of Acute Overdoses With L-Thyroxin in Children

Pediatr Emerg Care. 2019 Nov;35(11):787-790. doi: 10.1097/PEC.0000000000001141.

Abstract

Objectives: L-Thyroxine ingestion is rarely seen in children; here, we report our experience of it. This study describes the clinical characteristics and laboratory findings of acute L-thyroxine ingestion in children.

Methods: This retrospective study enrolled patients treated for L-thyroxine ingestion at Kayseri Teaching Hospital between September 2013 and September 2016. Clinical characteristics and laboratory findings are described. Ethical approval was not obtained because the study was retrospective.

Results: The incidence of L-thyroxine ingestion was 0.07% to 1.2% per year. There were 14 patients. Twelve patients were asymptomatic, but 2 (14.2%) exhibited tachycardia and hypertension. Thyroid hormone levels were elevated in 3 patients (21.4%). Eleven patients did not require medical treatment (78.4%); 3 did. No serious complication or death was observed.

Conclusions: Acute ingestion has a benign course. Serious complications are uncommon but may appear several hours or days after ingestion; therefore, patients with L-thyroxine ingestion should be followed closely for 2 weeks.

MeSH terms

  • Drug Overdose / epidemiology
  • Female
  • Hospitalization / statistics & numerical data
  • Humans
  • Hypertension / etiology
  • Male
  • Tachycardia / etiology
  • Thyroid Hormones / blood
  • Thyroxine / poisoning*

Substances

  • Thyroid Hormones
  • Thyroxine