Plasma Interferon-Gamma-Inducible Protein 10 Level Associates With Abnormal Memory B Cells Phenotypes in Perinatal HIV Infection

Pediatr Infect Dis J. 2017 Sep;36(9):e219-e222. doi: 10.1097/INF.0000000000001612.

Abstract

We demonstrate for perinatally HIV-infected children and adolescents receiving combined antiretroviral therapy and in good clinical status with respect to HIV disease that high concentrations of interferon-gamma-inducible protein 10 associate with increased exhausted memory B cells.

MeSH terms

  • Adolescent
  • Adult
  • B-Lymphocytes / immunology*
  • Chemokine CXCL10 / blood*
  • Chemokine CXCL10 / immunology
  • Child
  • Cross-Sectional Studies
  • Female
  • HIV Infections / blood*
  • HIV Infections / epidemiology*
  • HIV Infections / immunology
  • HIV Infections / physiopathology
  • HIV-1 / immunology
  • Humans
  • Infant, Newborn
  • Middle Aged
  • Phenotype
  • Pregnancy

Substances

  • CXCL10 protein, human
  • Chemokine CXCL10