Long non-coding RNAs in cutaneous melanoma: clinical perspectives

Oncotarget. 2017 Jun 27;8(26):43470-43480. doi: 10.18632/oncotarget.16478.

Abstract

Metastatic melanoma of the skin has a high mortality despite the recent introduction of targeted therapy and immunotherapy. Long non-coding RNAs (lncRNAs) are defined as transcripts of more than 200 nucleotides in length that lack protein-coding potential. There is growing evidence that lncRNAs play an important role in gene regulation, including oncogenesis. We present 13 lncRNA genes involved in the pathogenesis of cutaneous melanoma through a variety of pathways and molecular interactions. Some of these lncRNAs are possible biomarkers or therapeutic targets for malignant melanoma.

Keywords: biomarkers; cancer therapy; long non-coding RNA; melanoma.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor*
  • Epistasis, Genetic
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Melanoma / drug therapy
  • Melanoma / genetics*
  • Melanoma / mortality
  • Melanoma / pathology
  • Melanoma, Cutaneous Malignant
  • Mutation
  • Prognosis
  • RNA, Long Noncoding / genetics*
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / mortality
  • Skin Neoplasms / pathology

Substances

  • Biomarkers, Tumor
  • RNA, Long Noncoding