Spotlight on vitamin D receptor, lipid metabolism and mitochondria: Some preliminary emerging issues

Francesca Silvagno; Gianpiero Pescarmona

doi:10.1016/j.mce.2017.04.013

Spotlight on vitamin D receptor, lipid metabolism and mitochondria: Some preliminary emerging issues

Mol Cell Endocrinol. 2017 Jul 15:450:24-31. doi: 10.1016/j.mce.2017.04.013. Epub 2017 Apr 13.

Authors

Francesca Silvagno¹, Gianpiero Pescarmona²

Affiliations

¹ Department of Oncology, University of Torino, Via Santena 5 bis, 10126 Torino, Italy. Electronic address: francesca.silvagno@unito.it.
² Department of Oncology, University of Torino, Via Santena 5 bis, 10126 Torino, Italy. Electronic address: gianpiero.pescarmona@unito.it.

PMID: 28414049
DOI: 10.1016/j.mce.2017.04.013

Abstract

Transcriptional control and modulation of calcium fluxes underpin the differentiating properties of vitamin D (1,25(OH)₂D₃). In the latest years however few studies have pointed out the relevance of the mitochondrial effects of the hormone. It is now time to focus on the metabolic results of vitamin D receptor (VDR) action in mitochondria, which can explain the pleiotropic effects of 1,25(OH)₂D₃ and may elucidate few contrasting aspects of its activity. The perturbation of lipid metabolism described in VDR knockout mice and vitamin D deficient animals can be revisited based on the newly identified mechanism of action of 1,25(OH)₂D₃ in mitochondria. From the same point of view, the controversial role of 1,25(OH)₂D₃ in adipogenesis can be better interpreted.

Keywords: 1,25(OH)(2)D(3); Adipogenesis; Lipid metabolism; Mitochondrial metabolism; Vitamin D receptor; Vitamin D/VDR deficiency.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adipogenesis
Animals
Humans
Lipid Metabolism*
Mitochondria / metabolism*
Models, Biological
Phenotype
Receptors, Calcitriol / metabolism*

Substances

Receptors, Calcitriol