Genetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population

PLoS One. 2017 Apr 14;12(4):e0175666. doi: 10.1371/journal.pone.0175666. eCollection 2017.

Abstract

Non-small cell lung cancer is one of the most common cancers and the leading cause of cancer death worldwide. Genetic variants in regulatory regions of some miRNAs might be involved in non-small cell lung cancer susceptibility and survival. rs12220909 (G/C) genetic polymorphism in miR-4293 has been shown to be associated with decreased risk of esophageal squamous cell carcinoma. However, the influence of rs12220909 genetic variation on non-small cell lung cancer susceptibility has not been reported. In order to evaluate the potential association between miR-4293 rs12220909 and non-small cell lung cancer risk in a Chinese population, we performed a case-control study among 998 non-small cell lung cancer cases and 1471 controls. The data shows that miR-4293 rs12220909 was significantly associated with decreased susceptibility to non-small cell lung cancer (GC vs.GG: OR = 0.681, 95%CI = 0.555-0.835, P = 2.19E-4; GG vs. GC+CC: OR = 0.687, 95%CI = 0.564-0.837, P = 1.95E-4), which indicates that rs12220909 in miR-4293 may play a significant role in the development of non-small cell lung cancer.

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Asian People / genetics*
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Case-Control Studies
  • China
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genetic Variation*
  • Genotype
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • Male
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Single Nucleotide
  • Risk Factors

Substances

  • MicroRNAs

Grants and funding

Support was provided by the National Natural Science Foundation of China (grant number 81071957) (MW received the funding); the Key Project in the National Science & Technology Pillar Program (grant number 2011BAI09B00) (LJ received the funding); Suzhou City Science and Technology Program (grant number SYS201419) (MW received the funding).