Chemical constituents from the whole plants of Pilea cavaleriei Levl subsp. cavaleriei

Fitoterapia. 2017 Jun:119:100-107. doi: 10.1016/j.fitote.2017.04.010. Epub 2017 Apr 11.

Abstract

Three new sesquiterpene glycosides (1-3), three new glycerol glycosides (4-6), two new alkaloids (7-8), together with seven known compounds (9-15) all of which were isolated from the genus Pilea for the first time, were isolated from the whole plants of Pilea cavaleriei Levl subsp. cavaleriei. Their structures were determined by extensive spectroscopic techniques and chemical methods. The cytotoxic activity of the isolated compounds was evaluated against four cancer cell lines, and none of the tested compounds caused a significant reduction of the cell number.

Keywords: Alkaloids; Cytotoxic activity; Glycerol glycosides; Pilea cavaleriei Levl subsp. cavaleriei; Sesquiterpene glycosides.

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Cell Line, Tumor
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Humans
  • Molecular Structure
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Urticaceae / chemistry*

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Glycosides
  • Sesquiterpenes