Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis

Deobrat Dixit; Qi Xie; Jeremy N Rich; Jing Crystal Zhao

doi:10.1016/j.ccell.2017.03.010

Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis

Cancer Cell. 2017 Apr 10;31(4):474-475. doi: 10.1016/j.ccell.2017.03.010.

Authors

Deobrat Dixit¹, Qi Xie¹, Jeremy N Rich², Jing Crystal Zhao³

Affiliations

¹ Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
² Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address: drjeremyrich@gmail.com.
³ Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: czhao@sbpdiscovery.org.

Abstract

Messenger RNA (mRNA) modification provides an additional layer of gene regulation in cells. In this issue of Cancer Cell, Zhang et al. report that ALKBH5, a demethylase of the mRNA modification N⁶-methyladenosine, regulates proliferation and self-renewal of glioblastoma stem-like cells by modulating pre-mRNA stability and expression of the FOXM1 gene.

Publication types

Comment

MeSH terms

Carcinogenesis
Cell Transformation, Neoplastic
Glioblastoma / genetics*
Humans
Methylation
RNA, Messenger*

Substances

RNA, Messenger

Grants and funding

R01 GM110090/GM/NIGMS NIH HHS/United States