[Successful treatment of severe dabigatran intoxication with idarucizumab in a patient with acute kidney injury]

Ugeskr Laeger. 2017 Feb 13;179(7):V08160562.
[Article in Danish]

Abstract

In the course of an uncomplicated sigmoidostomy a 63-year-old male who had severe comorbidity developed a critical bleeding due to dabigatran intoxication induced by acute kidney injury. Massive blood transfusions, tranexamic acid, Octaplex and haemodialysis were not effective. Administration of idarucizumab induced immediate clinical and paraclinical improvement. Dabigatran should be carefully administrated in patients who have any degree of renal insufficiency. Idarucizumab may be effective in severe bleeding caused by dabigatran.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / complications
  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Antidotes / therapeutic use*
  • Antithrombins / poisoning*
  • Dabigatran / poisoning*
  • Drug Overdose / drug therapy*
  • Hemorrhage / chemically induced
  • Hemorrhage / drug therapy*
  • Humans
  • Male
  • Middle Aged
  • Thrombelastography

Substances

  • Antibodies, Monoclonal, Humanized
  • Antidotes
  • Antithrombins
  • idarucizumab
  • Dabigatran