Talaromyces marneffei is a dimorphic fungus, which may cause life-threatening opportunistic infections in immuno-compromised individuals. A 25-year-old woman from Thailand was admitted with fever, shortness of breath, cough, and weight loss. The symptoms had persisted for three weeks. The patient had a stopover in Copenhagen on her way to Thailand from Greenland. A thoracic X-ray showed bilateral interstitial changes. Examinations showed positive HIV-test with a CD4-count of 21/microlitre. Moreover, fungaemia with T. marneffei was detected by cultivation. Highly active antiretroviral therapy and IV amphotericin B treatment was initiated followed by perorally administrated itraconazole.