Catalytic Asymmetric Electrochemical Oxidative Coupling of Tertiary Amines with Simple Ketones

Niankai Fu; Longji Li; Qi Yang; Sanzhong Luo

doi:10.1021/acs.orglett.7b00746

Catalytic Asymmetric Electrochemical Oxidative Coupling of Tertiary Amines with Simple Ketones

Org Lett. 2017 Apr 21;19(8):2122-2125. doi: 10.1021/acs.orglett.7b00746. Epub 2017 Apr 10.

Authors

Niankai Fu^{1

2

3}, Longji Li^{1

2}, Qi Yang^{1

2}, Sanzhong Luo^{1

2

3}

Affiliations

¹ Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
² Department of Chemistry, University of Chinese Academy of Sciences , 10049 Beijing, China.
³ Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, China.

PMID: 28394132
DOI: 10.1021/acs.orglett.7b00746

Abstract

Catalytic asymmetric electrochemical C-H functionalization of simple ketones has been developed. The transformation is realized by the combination of electrochemical oxidation and chiral primary amine catalysis. This metal- and oxidant-free method furnishes diverse C1-alkylated tetrahydroisoquinolines in high yields and with excellent enantioselectivities under very mild conditions.

Publication types

Research Support, Non-U.S. Gov't