Blood to skin recirculation of CD4+ memory T cells associates with cutaneous and systemic manifestations of psoriatic disease

Abstract

Blood to skin recirculation could play a role in the pathogenesis of psoriasis. To investigate this possibility we dissected the phenotype of circulating T cells in psoriasis patients, calculated the correlation the clinical parameters of the disease and performed a parallel bioinformatics analysis of gene expression data in psoriatic skin. We found that circulating CCR6⁺ CD4⁺ T_EM and T_EFF cells significantly correlated with systemic inflammation. Conversely, the percentage of CXCR3⁺ CD4⁺ T_EM cells negatively correlated with the severity of the cutaneous disease. Importantly CLA⁺ CD4⁺ T_CM cells expressing CCR6⁺ or CCR4⁺CXCR3⁺ negatively correlated with psoriasis severity suggesting recruitment to the skin compartment. This assumption was reinforced by gene expression data showing marked increase of CCR7 and CLA-encoding gene SELPLG expression in psoriatic skin and strong association of their expression. The data enlightens a role for CD4⁺ T cells trafficking between blood and skin in cutaneous and systemic manifestations of psoriasis.