Grey matter reduction in the caudate nucleus in patients with persistent negative symptoms: An ALE meta-analysis

Ying Li; Wen-Xiu Li; Dong-Jie Xie; Yi Wang; Eric F C Cheung; Raymond C K Chan

doi:10.1016/j.schres.2017.04.005

Grey matter reduction in the caudate nucleus in patients with persistent negative symptoms: An ALE meta-analysis

Schizophr Res. 2018 Feb:192:9-15. doi: 10.1016/j.schres.2017.04.005. Epub 2017 Apr 5.

Authors

Ying Li¹, Wen-Xiu Li², Dong-Jie Xie³, Yi Wang⁴, Eric F C Cheung⁵, Raymond C K Chan⁶

Affiliations

¹ Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Haidian District Mental Health Prevent-Treatment Hospital, Beijing, China.
² Haidian District Mental Health Prevent-Treatment Hospital, Beijing, China.
³ Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
⁴ Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
⁵ Castle Peak Hospital, Hong Kong Special Administration Region, China.
⁶ Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address: rckchan@psych.ac.cn.

PMID: 28390850
DOI: 10.1016/j.schres.2017.04.005

Abstract

Objectives: In the present study, we used Activation Likelihood Estimation (ALE) meta-analysis to quantitatively examine brain grey matter reduction in schizophrenia patients with persistent negative symptoms (PNS).

Method: A total of 12 voxel-based morphometry (VBM) studies were included in ALE meta-analysis using more stringent criterion of PNS.

Results: Significant grey matter reduction in the PNS group relative to controls was observed in the left caudate nucleus, the left precentral region, the left middle frontal region, the bilateral parahippocampal region, the left anterior cingulate region, the bilateral medial frontal gyrus, the thalamus and the insula.

Conclusion: Our results suggest that brain regions in the reward network may be specifically related to PNS, especially the left caudate nucleus. It is possible that abnormality in reward processing may constitute the neural basis of PNS.

Keywords: Grey matter; Meta-analysis; Persistent negative symptoms; Schizophrenia.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review

MeSH terms

Caudate Nucleus / diagnostic imaging*
Caudate Nucleus / pathology
Gray Matter / diagnostic imaging*
Gray Matter / pathology
Humans
Organ Size
Schizophrenia / diagnostic imaging*
Schizophrenia / pathology
Schizophrenic Psychology*