Biomarkers for Adverse Pregnancy Outcomes in Rheumatic Diseases

Abstract

Pregnancy is a delicate balance of angiogenic factors. Adverse pregnancy outcomes in the form of placental insufficiency occur when antiangiogenic factors predominate, which manifests as maternal-placental syndrome (MPS). Women with rheumatic disease are at increased risk of MPS. Endothelial damage from circulating antiangiogenic factors and other inflammatory molecules in combination with preexisting maternal vascular risk factors is the likely underlying pathophysiological process for MPS. It is likely that these changes persist, and additional "insults" from ongoing inflammation, medications, and disease damage contribute to the development of accelerated cardiovascular disease seen in young women with rheumatic disease.

Keywords: Adverse pregnancy outcomes; Cardiovascular disease; Endothelial damage; Growth restriction; Placental growth factor; Preeclampsia; SLE; Soluble fms-like tyrosine kinase-1.