Acute Facial Nerve Palsy With Ipsilateral Soft Palate Ulcers

J Oral Maxillofac Surg. 2017 Sep;75(9):1906-1914. doi: 10.1016/j.joms.2017.02.025. Epub 2017 Mar 14.

Abstract

Ramsay-Hunt syndrome (RHS) is a rare complication of herpes zoster in which reactivation of latent varicella zoster virus (VZV) infection occurs in the geniculate ganglion. Major clinical findings are peripheral facial nerve palsy accompanied by ipsilateral ear pain and erythematous vesicular rash on the external ear (herpes zoster oticus) and in the mouth. Thus, diagnosis of RHS is usually clinical. However, auricular herpetic eruption is not always present, making diagnosis more difficult. This report describes a case of RHS with left facial palsy without skin lesions in 60-year-old woman. Multiple ulcers were found on her left soft palate. Polymerase chain reaction analysis on oral mucosa biopsy samples and serologic assays allowed the identification of VZV as the causal agent. Knowledge of the anatomy of the facial nerve is important for oral and maxillofacial surgeons when dealing with patients with RHS, especially in unusual and clinically misleading forms of this syndrome.

MeSH terms

  • Acute Disease
  • Acyclovir / analogs & derivatives
  • Acyclovir / therapeutic use
  • Antiviral Agents / therapeutic use
  • Female
  • Glucocorticoids / therapeutic use
  • Herpesvirus 3, Human / isolation & purification*
  • Humans
  • Middle Aged
  • Oral Ulcer / drug therapy
  • Oral Ulcer / virology*
  • Palate, Soft
  • Parkinsonian Disorders / drug therapy
  • Parkinsonian Disorders / virology*
  • Prednisolone / therapeutic use
  • Valacyclovir
  • Valine / analogs & derivatives
  • Valine / therapeutic use

Substances

  • Antiviral Agents
  • Glucocorticoids
  • Prednisolone
  • Valine
  • Valacyclovir
  • Acyclovir