New Avermectin Analogues from a Mutant Streptomyces avermectinius Strain

Youjun Zhang; Cheng Zhang; Keke Wang; Guoliang Chen; Peng Sun

doi:10.1002/cbdv.201700054

New Avermectin Analogues from a Mutant Streptomyces avermectinius Strain

Chem Biodivers. 2017 Jul;14(7). doi: 10.1002/cbdv.201700054. Epub 2017 Jun 2.

Authors

Youjun Zhang^{1

2}, Cheng Zhang¹, Keke Wang¹, Guoliang Chen², Peng Sun¹

Affiliations

¹ Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433, P. R. China.
² Department of Naval Health Service and Medical Equipment, Faculty of Medicine, Second Military Medical University, 800 Xiang-Yin Road, Shanghai, 200433, P. R. China.

PMID: 28387012
DOI: 10.1002/cbdv.201700054

Abstract

Two new avemectin analogues 1 and 2 belonging to 'b' series of components were isolated from a ∆aveCDE mutant Streptomyces avermectinius strain. Their structures were elucidated by detailed analysis of NMR and MS spectroscopic data. Compounds 1 and 2 displayed moderate cytotoxicities against B16, MG-63, and Saos-2 cell lines in an in vitro assay.

Keywords: Streptomyces avermectinius; Avemectin; Cytotoxic activities; Mutant strain; Structural elucidation.

MeSH terms

Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Cell Death / drug effects
Cell Line, Tumor
Humans
Ivermectin / analogs & derivatives*
Ivermectin / chemistry
Ivermectin / isolation & purification
Melanoma, Experimental / pathology
Molecular Structure
Mutation
Spectrum Analysis
Streptomyces / chemistry*
Streptomyces / genetics

Substances

Antineoplastic Agents
Ivermectin
avermectin