Genome Sequence of the Fungal Strain 14919 Producing 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitor FR901512

Hiroya Itoh; Makoto Matsui; Toshitaka Kumagai; Masanori Arita; Masayuki Machida; Takashi Shibata

doi:10.1128/genomeA.00129-17

Genome Sequence of the Fungal Strain 14919 Producing 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitor FR901512

Genome Announc. 2017 Apr 6;5(14):e00129-17. doi: 10.1128/genomeA.00129-17.

Authors

Hiroya Itoh^{1

2}, Makoto Matsui^{3

2}, Toshitaka Kumagai^{2

4}, Masanori Arita^{2

5}, Masayuki Machida^{2

6}, Takashi Shibata^{3

2}

Affiliations

¹ Biotechnology Labs, Astellas Pharma, Inc., Ibaraki, Japan hiroya.ito@astellas.com.
² Technology Research Association of Highly Efficient Gene Design (TRAHED), Hokkaido, Japan.
³ Biotechnology Labs, Astellas Pharma, Inc., Ibaraki, Japan.
⁴ Fermlab, Inc., Tokyo, Japan.
⁵ National Institute of Genetics, Shizuoka, Japan.
⁶ Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Sapporo, Hokkaido, Japan.

Abstract

Fungal strain 14919 was originally isolated from a soil sample collected at Mt. Kiyosumi, Chiba Prefecture, Japan. It produces FR901512, a potent and strong 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. The genome sequence of fungal strain 14919 was determined and annotated to improve the productivity of FR901512.