Role of miR-15a/miR-16-1 and the TP53 axis in regulating telomerase expression in chronic lymphocytic leukemia

Haematologica. 2017 Jul;102(7):e253-e256. doi: 10.3324/haematol.2016.157669. Epub 2017 Apr 6.

Authors

Affiliations

¹ Department of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova.
² Department of Clinical and Experimental Medicine, Hematology Section, University of Padova.
³ Istituto Oncologico Veneto-IRCCS, Padova, Italy.
⁴ Department of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, University of Padova anita.derossi@unipd.it.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Biomarkers, Tumor
Chromosome Aberrations
Female
Gene Expression Regulation, Leukemic*
Genes, Immunoglobulin
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Leukemia, Lymphocytic, Chronic, B-Cell / metabolism
Leukemia, Lymphocytic, Chronic, B-Cell / mortality
Male
MicroRNAs / genetics*
Middle Aged
Prognosis
Proportional Hazards Models
Signal Transduction
Telomerase / genetics*
Telomerase / metabolism
Tumor Suppressor Protein p53 / genetics*
Tumor Suppressor Protein p53 / metabolism

Substances

Biomarkers, Tumor
MIRN15 microRNA, human
MIRN16 microRNA, human
MicroRNAs
TP53 protein, human
Tumor Suppressor Protein p53
Telomerase