β-Cyclodextrin-based supramolecular poly(N-isopropylacrylamide) hydrogels prepared by frontal polymerization

D Sanna; V Alzari; D Nuvoli; L Nuvoli; M Rassu; V Sanna; A Mariani

doi:10.1016/j.carbpol.2017.02.099

β-Cyclodextrin-based supramolecular poly(N-isopropylacrylamide) hydrogels prepared by frontal polymerization

Carbohydr Polym. 2017 Jun 15:166:249-255. doi: 10.1016/j.carbpol.2017.02.099. Epub 2017 Feb 24.

Authors

D Sanna¹, V Alzari², D Nuvoli³, L Nuvoli⁴, M Rassu⁵, V Sanna⁶, A Mariani⁷

Affiliations

¹ Department of Chemistry and Pharmacy, and INSTM Unit, via Vienna 2, 07100 Sassari, Italy. Electronic address: dvdsanna@uniss.it.
² Department of Chemistry and Pharmacy, and INSTM Unit, via Vienna 2, 07100 Sassari, Italy. Electronic address: valzari@uniss.it.
³ Department of Chemistry and Pharmacy, and INSTM Unit, via Vienna 2, 07100 Sassari, Italy. Electronic address: dnuvoli@uniss.it.
⁴ Department of Chemistry and Pharmacy, and INSTM Unit, via Vienna 2, 07100 Sassari, Italy. Electronic address: lunuvoli@uniss.it.
⁵ Department of Chemistry and Pharmacy, and INSTM Unit, via Vienna 2, 07100 Sassari, Italy. Electronic address: mariella.rassu88@gmail.com.
⁶ Department of Chemistry and Pharmacy, and INSTM Unit, via Vienna 2, 07100 Sassari, Italy. Electronic address: vsanna@uniss.it.
⁷ Department of Chemistry and Pharmacy, and INSTM Unit, via Vienna 2, 07100 Sassari, Italy. Electronic address: mariani@uniss.it.

PMID: 28385230
DOI: 10.1016/j.carbpol.2017.02.099

Abstract

Frontal polymerization (FP) was successfully applied to the synthesis of poly(N-isopropylacrylamide)-grafted-acryloyl-β-cyclodextrin supramolecularly crosslinked hydrogels. It was established that acryloyl-β-cyclodextrin (AβCD) allowed performing successful frontal polymerizations with N-isopropylacrylamide even in the absence of any covalent crosslinker, which is something generally required. It was found that the swelling properties of the resulting hydrogels can be tuned by varying the amount of AβCD. Namely, when little amounts of this non-covalent crosslinker were used, superabsorbent hydrogels were obtained. Hydrogels containing also a covalent crosslinker were also prepared for comparison. These latter exhibited swelling ratios that are much lower than the others.

Keywords: Dimethylsulfoxide (PubChem CID: 679); Frontal polymerization; N,N′-methylene-bis-acrylamide (PubChem CID: 168964); N-isopropylacrylamide (PubChem CID: 16637); Supramolecular hydrogel; Swelling ratio; β-Cyclodextrin.