Iatrogenic Calcinosis Cutis Successfully Treated with Topical Sodium Thiosulfate

Pediatr Dermatol. 2017 May;34(3):356-358. doi: 10.1111/pde.13116. Epub 2017 Apr 6.

Abstract

Calcinosis cutis is a term used to describe a group of disorders in which calcium salt deposits form in the skin and subcutaneous tissue. We report a 6-year-old boy with hypoparathyroidism after thyroidectomy who was admitted to the hospital for severe hypocalcemia being treated with calcium gluconate intravenous infusion through peripheral veins. Within a few days we made a diagnosis of iatrogenic calcinosis cutis and treatment with 10% topical sodium thiosulfate was prescribed; complete resolution of lesions was achieved after 6 months, with no local or systemic adverse effects. Because of the lack of noninvasive alternatives and the good tolerance of the treatment, especially in childhood, we suggest the topical use of this drug as an option for this condition.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Calcinosis / drug therapy*
  • Child
  • Humans
  • Iatrogenic Disease
  • Male
  • Skin Diseases / drug therapy*
  • Skin Diseases / etiology
  • Thiosulfates / administration & dosage*

Substances

  • Thiosulfates
  • sodium thiosulfate