A Novel Protective Role for FXR against Inflammasome Activation and Endotoxemia

Oihane Garcia-Irigoyen; Antonio Moschetta

doi:10.1016/j.cmet.2017.03.014

A Novel Protective Role for FXR against Inflammasome Activation and Endotoxemia

Cell Metab. 2017 Apr 4;25(4):763-764. doi: 10.1016/j.cmet.2017.03.014.

Authors

Oihane Garcia-Irigoyen¹, Antonio Moschetta²

Affiliations

¹ Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy; INBB, National Institute for Biostructures and Biosystems, 00136 Rome, Italy; National Cancer Research Center, IRCCS Istituto Oncologico "Giovanni Paolo II," 70124 Bari, Italy.
² Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy; INBB, National Institute for Biostructures and Biosystems, 00136 Rome, Italy; National Cancer Research Center, IRCCS Istituto Oncologico "Giovanni Paolo II," 70124 Bari, Italy. Electronic address: antonio.moschetta@uniba.it.

PMID: 28380370
DOI: 10.1016/j.cmet.2017.03.014

Abstract

During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis.

Keywords: FXR; bile acids; cholestasis; inflammasome; nuclear receptors; sepsis.

Publication types

Comment

MeSH terms

Bile Acids and Salts*
Cholestasis
Endotoxemia
Humans
Inflammasomes*
Receptors, Cytoplasmic and Nuclear

Substances

Bile Acids and Salts
Inflammasomes
Receptors, Cytoplasmic and Nuclear