Brown Fat-Derived Exosomes: Small Vesicles with Big Impact

Yong Chen; Alexander Pfeifer

doi:10.1016/j.cmet.2017.03.012

Brown Fat-Derived Exosomes: Small Vesicles with Big Impact

Cell Metab. 2017 Apr 4;25(4):759-760. doi: 10.1016/j.cmet.2017.03.012.

Authors

Yong Chen¹, Alexander Pfeifer²

Affiliations

¹ Institute of Pharmacology and Toxicology, University of Bonn, 53127 Bonn, Germany.
² Institute of Pharmacology and Toxicology, University of Bonn, 53127 Bonn, Germany. Electronic address: alexander.pfeifer@uni-bonn.de.

PMID: 28380368
DOI: 10.1016/j.cmet.2017.03.012

Abstract

Adipose tissue (AT) not only stores energy, but also secretes hormones and releases small vesicles known as exosomes. Thomou et al. (2017) now show that exosomes secreted by brown fat carry miRNAs that regulate the liver. Thus, AT exosomes might have therapeutic and diagnostic relevance for metabolic disorders.

Keywords: FGF21; biomarker; brown adipose tissue; exosomes; liver; microRNAs; white adipose tissue.

Publication types

Comment

MeSH terms

Adipose Tissue, Brown*
Exosomes*
Humans
Liver
Metabolic Diseases
MicroRNAs

Substances

MicroRNAs