Specific Polysaccharide Antibody Deficiency Revealed by Severe Bacterial Infections in Adulthood: A Report on 11 Cases

Clin Infect Dis. 2017 Jul 15;65(2):328-331. doi: 10.1093/cid/cix284.

Abstract

We report on 11 cases of specific polysaccharide antibody deficiency (SPAD) revealed in adulthood by severe infections with encapsulated bacteria. Given that immunoglobulin replacement therapy can effectively prevent the recurrence of bacterial infections in this context, SPAD should be considered once other antibody deficiencies have been ruled out.

Keywords: Group A Streptococcus; Haemophilus influenzae type b; Streptococcus pneumonia; primary immunodeficiency; specific polysaccharide antibody deficiency.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Antibodies, Bacterial / immunology*
  • Bacterial Infections / immunology*
  • Bacterial Infections / microbiology
  • Bacterial Infections / therapy
  • Female
  • Humans
  • Immunization, Passive
  • Immunologic Deficiency Syndromes / diagnosis*
  • Immunologic Deficiency Syndromes / microbiology
  • Male
  • Middle Aged
  • Pneumococcal Infections / immunology
  • Pneumococcal Infections / microbiology
  • Pneumococcal Infections / therapy
  • Polysaccharides, Bacterial / immunology*
  • Streptococcus pneumoniae / immunology
  • Young Adult

Substances

  • Antibodies, Bacterial
  • Polysaccharides, Bacterial