Objective: To investigate the clinical significance of plasma levels of hypersensitive C-reactive protein (hs-CRP), fibriogen and D-dimmer (D-DI) in patients with connective tissue disease (CTD)-related interstitial lung disease (CTD-ILD).
Methods: Sixty-nine patients with interstitial lung disease admitted in Zhujiang Hospital between January, 2010 and April, 2016, including 29 with CTD-ILD and 40 with non-CTD-ILD were analyzed for plasma levels of hs-CRP, fibriogen and D-DI, with 25 healthy subjects as the control group.
Results: The plasma level of hs-CRP, fibriogen and D-DI in patients with CTD-ILD and non-CTD-ILD were all significantly higher than those in the control group. The patients with CTD-ILD had a significantly higher hs-CRP level than those with non-CTD-ILD, but the levels of fibriogen and D-DI were comparable between the two groups. Correlation analysis indicated that Hs-CRP level was positively correlated with the levels of D-DI (r=0.539, P<0.01) and fibrinogen (r=0.534, P<0.01).
Conclusion: Hs-CRP, fibriogen and D-DI levels show an important value in clinical diagnosis of CTD, and an obvious elevation of hs-CRP is correlated with the CTD.
目的: 观察超敏C反应蛋白、纤维蛋白原和D-二聚体在结缔组织病相关间质性肺炎（CTD-ILD）和非结缔组织病相关间质性肺炎（NCTD-ILD）患者血浆中的浓度高低，探究其相关性及临床意义。
方法: 选取2010年1月~2016年4月南方医科大学珠江医院收治的间质性肺炎患者69例，分为CTD-ILD组（30例）和NCTD-ILD组（39例）作为研究对象，同期纳入25例健康人作为对照组，行超敏C反应蛋白、纤维蛋白原和D-二聚体检测。
结果: CTD-ILD组和NCTD-ILD组的超敏C反应蛋白、纤维蛋白原和D-二聚体浓度均高于对照组（P＜0.05）；CTD-ILD组的超敏C反应蛋白浓度高于NCTD-ILD组（P＜0.05），但两组间的纤维蛋白原和D-二聚体浓度无差异；超敏C反应蛋白浓度分别与D-二聚体浓度、纤维蛋白原浓度呈正相关（r分别为0.539、0.534，P＜0.01）。
结论: 超敏C反应蛋白、纤维蛋白原和D-二聚体对间质性肺炎的临床诊断有重要意义，超敏C反应蛋白的明显升高与合并结缔组织病相关。