Diversity in AMPA receptor complexes in the brain

Eric Jacobi; Jakob von Engelhardt

doi:10.1016/j.conb.2017.03.001

Diversity in AMPA receptor complexes in the brain

Curr Opin Neurobiol. 2017 Aug:45:32-38. doi: 10.1016/j.conb.2017.03.001. Epub 2017 Apr 1.

Authors

Eric Jacobi¹, Jakob von Engelhardt²

Affiliations

¹ Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
² Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address: engelhardt@uni-mainz.de.

PMID: 28376410
DOI: 10.1016/j.conb.2017.03.001

Abstract

AMPA receptor (AMPAR) complexes comprise four of the AMPAR subunits GluA1-4 and several additional interacting proteins. Subunit composition determines AMPAR function. However, AMPAR function depends to a large extent also on interacting proteins, which influence trafficking to the cell surface, activity-dependent subcellular localization and gating of AMPARs. In this review we report about recent findings on the diversity of AMPAR complexes that allow us to better understand functional properties of native receptors in the brain.

Publication types

Review

MeSH terms

Animals
Brain / physiology*
Genetic Variation*
Humans
Protein Transport
Receptors, AMPA / genetics*
Receptors, AMPA / metabolism*

Substances

Receptors, AMPA