Cycloartane triterpenoid saponins from the herbs of Thalictrum fortunei

Carbohydr Res. 2017 Jun 5:445:1-6. doi: 10.1016/j.carres.2017.03.019. Epub 2017 Mar 30.

Abstract

Six new cycloartane triterpenoid saponins, thalisides A-F (1-6), along with four known ones (7-10), were isolated from Thalictrum fortunei. The new structures were elucidated by using spectroscopic data (NMR, IR, UV, and MS). Compounds 1-10 were examined for their in vitro cytotoxicity against two human cancer cell lines (HepG2, A549) and antiviral activity against influenza A virus (H1N1) and found to be inactive.

Keywords: Antiviral activity; Cycloartane triterpenoid saponins; Cytotoxicity; Thalictrum fortunei.

MeSH terms

  • A549 Cells
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology
  • Hep G2 Cells
  • Humans
  • Influenza A Virus, H1N1 Subtype / drug effects
  • Saponins / chemistry*
  • Saponins / isolation & purification
  • Saponins / pharmacology*
  • Thalictrum / chemistry*
  • Triterpenes / chemistry*

Substances

  • Antineoplastic Agents
  • Antiviral Agents
  • Saponins
  • Triterpenes
  • cycloartane