Advance of DNA and CCPs-based nanocarriers in drug delivery systems

Biomed Mater Eng. 2017;28(s1):S255-S261. doi: 10.3233/BME-171648.

Abstract

Development of smart and functional polymeric carriers, which enable controlled or timed release of a bioactive material, thereby providing a better dosing pattern and minimizing side effects, becomes a new requirement in the field of drug delivery. In the recent few decades, a great many advancements of polymer synthetic methods have led to a new generation of bioactive polymers' applications as drug controlled release carriers. In this review, we focus on the use of bioactive polymers for drug delivery system, with a particular in the utility of DNA-based nanocarriers and cell-penetrating peptides (CCPs)-based nanocarriers to provide precision control for drug targeting or stimuli responsive systems.

Keywords: DNA; cell-penetrating peptides; drug delivery systems; nanocarriers; targeting.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell-Penetrating Peptides / chemistry*
  • Cell-Penetrating Peptides / metabolism
  • DNA / chemistry*
  • DNA / metabolism
  • Drug Carriers / chemistry*
  • Drug Carriers / metabolism
  • Drug Delivery Systems
  • Humans
  • Nanostructures / chemistry*

Substances

  • Cell-Penetrating Peptides
  • Drug Carriers
  • DNA