A One-Pot Multicomponent 1,3-Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Dihydrothiophenone-Engrafted Dispiro Hybrid Heterocycles

Mani Anusha Rani; Sundaravel Vivek Kumar; Karuppiah Malathi; Muthumani Muthu; Abdulrahman I Almansour; Raju Suresh Kumar; Raju Ranjith Kumar

doi:10.1021/acscombsci.6b00186

A One-Pot Multicomponent 1,3-Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Dihydrothiophenone-Engrafted Dispiro Hybrid Heterocycles

ACS Comb Sci. 2017 May 8;19(5):308-314. doi: 10.1021/acscombsci.6b00186. Epub 2017 Apr 11.

Authors

Mani Anusha Rani¹, Sundaravel Vivek Kumar¹, Karuppiah Malathi¹, Muthumani Muthu¹, Abdulrahman I Almansour², Raju Suresh Kumar², Raju Ranjith Kumar¹

Affiliations

¹ Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University , Madurai-625021, Tamil Nadu, India.
² Department of Chemistry, College of Science, King Saud University , P.O. Box 2455, Riyadh 11451, Saudi Arabia.

PMID: 28371579
DOI: 10.1021/acscombsci.6b00186

Abstract

The combinatorial syntheses of a library of novel dihydrothiophenone-engrafted dispiro oxindole/indenoquinoxaline-pyrrolidine/pyrrolothiazole/indolizine hybrid heterocycles have been realized through a chemo-, regio-, and stereoselective multicomponent 1,3-dipolar cycloaddition strategy.

Keywords: 1,3-dipolar cycloaddition; azomethine ylide; dihydrothiophen-3(2H)-ones; dispiro heterocycles; multicomponent reaction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Combinatorial Chemistry Techniques
Cycloaddition Reaction
Heterocyclic Compounds, Fused-Ring / chemical synthesis*
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Small Molecule Libraries / chemical synthesis*
Spiro Compounds / chemical synthesis*
Stereoisomerism
Structure-Activity Relationship
Thiophenes / chemical synthesis*

Substances

Heterocyclic Compounds, Fused-Ring
Small Molecule Libraries
Spiro Compounds
Thiophenes