Antidepressant-Like Effect of 1α-Hydroxyvitamin D3 on Mice in the Forced Swimming Test

Akihiko Kawaura; Yoshihisa Kitamura; Noritoshi Tanida; Junichi Akiyama; Masatoshi Mizutani; Kazuhiro Harada; Motoyoshi Morishita; Shigeki Inoue; Yoshio Kano; Toshio Okano; Eiji Takeda

doi:10.3177/jnsv.63.81

Antidepressant-Like Effect of 1α-Hydroxyvitamin D₃ on Mice in the Forced Swimming Test

J Nutr Sci Vitaminol (Tokyo). 2017;63(1):81-84. doi: 10.3177/jnsv.63.81.

Authors

Akihiko Kawaura¹, Yoshihisa Kitamura, Noritoshi Tanida, Junichi Akiyama, Masatoshi Mizutani, Kazuhiro Harada, Motoyoshi Morishita, Shigeki Inoue, Yoshio Kano, Toshio Okano, Eiji Takeda

Affiliation

¹ Department of Physical Therapy, School of Health Care and Social Welfare, KIBI International University.

PMID: 28367930
DOI: 10.3177/jnsv.63.81

Abstract

We examined the effect of 1α-hydroxyvitamin D₃ [1α(OH)D₃] on mice in the forced swimming test. Intragastric administration of 1.0 μg/kg of 1α(OH)D₃ reduced immobility time in the forced swimming test. At all concentrations tested (0.5, 1.0, 2.0 μg/kg), 1α(OH)D₃ had no effect on locomotor activity, compared with controls. These results suggest that 1α(OH)D₃ may have antidepressant-like activity.

MeSH terms

Animals
Antidepressive Agents*
Disease Models, Animal
Hydroxycholecalciferols / pharmacology*
Male
Mice
Mice, Inbred ICR
Swimming

Substances

Antidepressive Agents
Hydroxycholecalciferols
alfacalcidol