Abstract
Three new coumarin glycosides (1-3), together with three known compounds (4-6), have been obtained from the stems of Hydrangea paniculata Sieb. Their structures were elucidated based on spectroscopic data and chemical evidence. In addition, compounds 1-3 were screened for their neuroprotective effects against serum deprivation-induced PC12 cell damage, hepatoprotective activities against DL-galactosamine-induced toxicity in HL-7702 cells and their ability to inhibit LPS-induced nitric oxide production in the murine microglia BV2 cell line, but they were inactive.
Keywords:
Hydrangea paniculata; anti-inflammatory; coumarin glycosides; hepatoprotective; neuroprotective.
MeSH terms
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Animals
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology
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Galactosamine / pharmacology
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Hydrangea / chemistry*
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Lipopolysaccharides / pharmacology
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Liver / drug effects
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Mice
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Microglia / drug effects
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification*
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Neuroprotective Agents / pharmacology
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Nitric Oxide / biosynthesis
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PC12 Cells
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Plant Stems / chemistry
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Rats
Substances
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8-methoxyl umbelliferone 7-O-beta-D-glucopyranosyl (1-6)-O-beta-D-glucopyranoside
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Coumarins
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Glycosides
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Lipopolysaccharides
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Neuroprotective Agents
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umbelliferone 7-O-beta-D-glucopyranosyl (1-2)-(beta-D-apiofuranosyl (1-6))-beta-D-glucopyranoside
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Nitric Oxide
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Galactosamine