Three new coumarin glycosides from the stems of Hydrangea paniculata

J Asian Nat Prod Res. 2017 Apr;19(4):320-326. doi: 10.1080/10286020.2017.1305958.

Abstract

Three new coumarin glycosides (1-3), together with three known compounds (4-6), have been obtained from the stems of Hydrangea paniculata Sieb. Their structures were elucidated based on spectroscopic data and chemical evidence. In addition, compounds 1-3 were screened for their neuroprotective effects against serum deprivation-induced PC12 cell damage, hepatoprotective activities against DL-galactosamine-induced toxicity in HL-7702 cells and their ability to inhibit LPS-induced nitric oxide production in the murine microglia BV2 cell line, but they were inactive.

Keywords: Hydrangea paniculata; anti-inflammatory; coumarin glycosides; hepatoprotective; neuroprotective.

MeSH terms

  • Animals
  • Coumarins / chemistry
  • Coumarins / isolation & purification*
  • Coumarins / pharmacology
  • Galactosamine / pharmacology
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Hydrangea / chemistry*
  • Lipopolysaccharides / pharmacology
  • Liver / drug effects
  • Mice
  • Microglia / drug effects
  • Molecular Structure
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / isolation & purification*
  • Neuroprotective Agents / pharmacology
  • Nitric Oxide / biosynthesis
  • PC12 Cells
  • Plant Stems / chemistry
  • Rats

Substances

  • 8-methoxyl umbelliferone 7-O-beta-D-glucopyranosyl (1-6)-O-beta-D-glucopyranoside
  • Coumarins
  • Glycosides
  • Lipopolysaccharides
  • Neuroprotective Agents
  • umbelliferone 7-O-beta-D-glucopyranosyl (1-2)-(beta-D-apiofuranosyl (1-6))-beta-D-glucopyranoside
  • Nitric Oxide
  • Galactosamine