DREF plays multiple roles during Drosophila development

Nguyen Trong Tue; Yasuhide Yoshioka; Megumi Mizoguchi; Hideki Yoshida; Mario Zurita; Masamitsu Yamaguchi

doi:10.1016/j.bbagrm.2017.03.004

DREF plays multiple roles during Drosophila development

Biochim Biophys Acta Gene Regul Mech. 2017 Jun;1860(6):705-712. doi: 10.1016/j.bbagrm.2017.03.004. Epub 2017 Mar 28.

Authors

Nguyen Trong Tue¹, Yasuhide Yoshioka², Megumi Mizoguchi³, Hideki Yoshida⁴, Mario Zurita⁵, Masamitsu Yamaguchi⁶

Affiliations

¹ Gene-Protein Research Center, Hanoi Medical University, Hanoi, Vietnam.
² Faculty of Science and Engineering, Setsunan University, Osaka, Japan.
³ Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
⁴ Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan; The Center for Advanced Insect Research, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
⁵ Departamento de Genética del Desarrollo Y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Col. Chamilpa, 62250 Cuernavaca, Mor., Mexico.
⁶ Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan; The Center for Advanced Insect Research, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. Electronic address: myamaguc@kit.ac.jp.

PMID: 28363744
DOI: 10.1016/j.bbagrm.2017.03.004

Abstract

DREF was originally identified as a transcription factor that coordinately regulates the expression of DNA replication- and proliferation-related genes in Drosophila. Subsequent studies demonstrated that DREF is involved in tumor suppressor pathways including p53 and Hippo signaling. DREF also regulates the expression of genes encoding components of the JNK and EGFR pathways during Drosophila development. DREF itself is under the control of the TOR pathway during cell and tissue growth responding to nutrition. Recent studies revealed that DREF plays a role in chromatin organization including insulator function, chromatin remodeling, and telomere maintenance. DREF is also involved in the regulation of genes related to mitochondrial biogenesis, linking it to cellular proliferation. Thus, DREF is now emerging as not only a transcription factor, but also a multi-functional protein. In this review, we summarize current advances in studies on the novel functions of Drosophila DREF.

Keywords: Chromatin remodeling; DREF; Insulator; Signal transduction; Telomere; Transcription; Tumor suppressor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Proliferation / physiology*
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
Drosophila melanogaster
Intracellular Signaling Peptides and Proteins / genetics
Intracellular Signaling Peptides and Proteins / metabolism
Mitochondria / genetics
Mitochondria / metabolism*
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism
Signal Transduction / physiology*
Transcription Factors / genetics
Transcription Factors / metabolism*
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / metabolism

Substances

Dref protein, Drosophila
Drosophila Proteins
Intracellular Signaling Peptides and Proteins
Transcription Factors
Tumor Suppressor Protein p53
Protein Serine-Threonine Kinases
hpo protein, Drosophila