Three novel indole alkaloids from Kopsia officinalis

Zhi-Wei Wang; Xiao-Jian Shi; Yan Mu; Lei Fang; Yue Chen; Yun-Liang Lin

doi:10.1016/j.fitote.2017.01.017

Three novel indole alkaloids from Kopsia officinalis

Fitoterapia. 2017 Jun:119:8-11. doi: 10.1016/j.fitote.2017.01.017. Epub 2017 Mar 28.

Authors

Zhi-Wei Wang¹, Xiao-Jian Shi², Yan Mu³, Lei Fang³, Yue Chen³, Yun-Liang Lin³

Affiliations

¹ Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Shandong Academy of Sciences, 19 Keyuan Street, Jinan, Shandong 250014, China. Electronic address: wzwcpu@126.com.
² Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Haike Road 501, Shanghai 201203, China.
³ Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Shandong Academy of Sciences, 19 Keyuan Street, Jinan, Shandong 250014, China.

PMID: 28363506
DOI: 10.1016/j.fitote.2017.01.017

Abstract

Three new indole alkaloids, named kopsioffines A-C (1-3), possessing relatively novel ten-membered lactam ring, and one known compound (11,12-demethoxy-16-deoxypauciflorine, 4) were isolated from the leaves and stems of Kopsia officinalis. Their structures were elucidated by means of spectroscopic methods. The absolute configuration of 1 was determined by calculated electronic circular dichroism data. The hypothetical biosynthetic pathway of 1 was postulated. All these isolates were evaluated for their inhibitory effects on α-glucosidase. None of them showed activity with IC₅₀ far beyond 50μM.

Keywords: Biosynthetic pathway; Indole alkaloid; Kopsia officinalis.

MeSH terms

Apocynaceae / chemistry*
Glycoside Hydrolase Inhibitors / chemistry
Glycoside Hydrolase Inhibitors / isolation & purification
Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Molecular Structure
Plant Leaves / chemistry
Plant Stems / chemistry
alpha-Glucosidases

Substances

Glycoside Hydrolase Inhibitors
Indole Alkaloids
alpha-Glucosidases