Nanomaterial scaffolds to regenerate musculoskeletal tissue: signals from within for neovessel formation

Zuyong Wang; Feng Wen; Poon Nian Lim; Qinyuan Zhang; Toshiisa Konishi; Dong Wang; Swee Hin Teoh; Eng San Thian

doi:10.1016/j.drudis.2017.03.010

Nanomaterial scaffolds to regenerate musculoskeletal tissue: signals from within for neovessel formation

Drug Discov Today. 2017 Sep;22(9):1385-1391. doi: 10.1016/j.drudis.2017.03.010. Epub 2017 Mar 28.

Authors

Zuyong Wang¹, Feng Wen², Poon Nian Lim³, Qinyuan Zhang³, Toshiisa Konishi⁴, Dong Wang³, Swee Hin Teoh², Eng San Thian⁵

Affiliations

¹ College of Materials Science and Engineering, Hunan University, Changsha 410082, PR China; Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117 576, Singapore.
² Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore.
³ Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117 576, Singapore.
⁴ Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117 576, Singapore; Graduate School of Natural Science and Technology, Okayama University, Okayama 7008530, Japan.
⁵ Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117 576, Singapore. Electronic address: mpetes@nus.edu.sg.

PMID: 28363083
DOI: 10.1016/j.drudis.2017.03.010

Abstract

Current treatments for musculoskeletal disease and injury are restricted with the usage of autografts and allografts. Tissue engineering that applies the principles of biology and engineering to develop functional substitutes has potential promise of therapeutic regeneration for musculoskeletal tissues. However, engineering sizable tissues needs a vascular network to supply cells with nutrients, oxygen and signals after implantation. For this purpose, recent developments on therapeutic nanomaterials have been explored in delivering different vessel-inductive growth factors, small biomolecules and ions for scalable engineering into vascularizable scaffolds. Here, we provide an overview on the current efforts, and propose future perspectives for precise regulation on vascularization processes and musculoskeletal tissue functionality.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bone Regeneration*
Humans
Muscle, Skeletal / physiology*
Nanostructures*
Neovascularization, Physiologic
Tissue Scaffolds*