Indole Alkaloids from Hunteria zeylanica

Mei-Fen Bao; Chun-Xia Zeng; Ya-Ping Liu; Bing-Jie Zhang; Ling Ni; Xiao-Dong Luo; Xiang-Hai Cai

doi:10.1021/acs.jnatprod.5b01035

Indole Alkaloids from Hunteria zeylanica

J Nat Prod. 2017 Apr 28;80(4):790-797. doi: 10.1021/acs.jnatprod.5b01035. Epub 2017 Mar 31.

Authors

Mei-Fen Bao^{1

2}, Chun-Xia Zeng³, Ya-Ping Liu^{1

2}, Bing-Jie Zhang^{1

2}, Ling Ni^{1

2}, Xiao-Dong Luo^{1

2}, Xiang-Hai Cai^{1

2}

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
² Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming 650201, People's Republic of China.
³ Germplasm Bank of Wild Species in Southwest China, Kunming Institute of Botany , Kunming 650201, People's Republic of China.

PMID: 28362501
DOI: 10.1021/acs.jnatprod.5b01035

Abstract

Six new bisindole alkaloids, hunterizeylines A-F (1-6), three new monomers, hunterizeylines G-I (7-9), and 13 known alkaloids were isolated from an aqueous MeOH extract of the twigs and leaves of Hunteria zeylanica. Hunterizeyline H, geissoschizol, and dihydrocorynantheol displayed weak insecticidal activity against the aphid Rhodobium porosum, with IC₅₀ values of 168.2, 360.5, and 290.6 μM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids
Animals
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology*
Aphids / drug effects
Apocynaceae / chemistry*
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal / chemistry
Drugs, Chinese Herbal / isolation & purification*
HeLa Cells
Humans
Insecticides / isolation & purification*
Insecticides / pharmacology*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Leaves / chemistry
Plants, Medicinal / chemistry*
Secologanin Tryptamine Alkaloids / chemistry
Secologanin Tryptamine Alkaloids / isolation & purification*

Substances

Alkaloids
Antineoplastic Agents, Phytogenic
Drugs, Chinese Herbal
Insecticides
Secologanin Tryptamine Alkaloids
dihydrocorynantheol