Abstract
The remarkable affinity of deca-carboxylatopillar[5]arene WP5 towards the aminoglycoside antibiotic, amikacin, in aqueous media is reported; in vitro studies on Gram-positive bacteria (Staphylococcus aureus) show that drug entrapment inside WP5 also takes place in the presence of the microrganisms, thus pointing to WP5 as an appealing carrier for amikacin targeted delivery.
MeSH terms
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Amikacin / chemistry*
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Amikacin / pharmacology
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Calixarenes
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Drug Carriers / chemistry*
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Quaternary Ammonium Compounds / chemistry*
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Solubility
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Staphylococcus aureus / drug effects
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Water / chemistry*
Substances
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Anti-Bacterial Agents
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Drug Carriers
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Quaternary Ammonium Compounds
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pillar(5)arene
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Water
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Calixarenes
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Amikacin