Effect of Metal-Containing Nanocomposites on Functional Status of the Thymus in Experimental Animals

V I Dubrovina; S V Balakhonov; V V Voitkova; S A Vityazeva; T P Starovoitova; K M Korytov; G F Prozorova; G P Aleksandrova; S I Kolesnikov

doi:10.1007/s10517-017-3683-4

Effect of Metal-Containing Nanocomposites on Functional Status of the Thymus in Experimental Animals

Bull Exp Biol Med. 2017 Mar;162(5):666-670. doi: 10.1007/s10517-017-3683-4. Epub 2017 Mar 31.

Authors

V I Dubrovina¹, S V Balakhonov², V V Voitkova², S A Vityazeva², T P Starovoitova², K M Korytov², G F Prozorova³, G P Aleksandrova³, S I Kolesnikov⁴

Affiliations

¹ Irkutsk Anti-Plague Research Institute of Siberia and the Far East, Irkutsk, Russia. dubrovina-valya@mail.ru.
² Irkutsk Anti-Plague Research Institute of Siberia and the Far East, Irkutsk, Russia.
³ A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Division of the Russian Academy of Sciences, Irkutsk, Russia.
⁴ Research Center of Family Health and Reproduction Problems, Irkutsk, Russia.

PMID: 28361422
DOI: 10.1007/s10517-017-3683-4

Abstract

The effects of nanostructurized composites argentogalactomannan and argento-poly-1-vinyl-1,2,4-triasole on the kinetics of T cell maturation in the thymus of albino mice were studied. These nanocomposites stimulated the formation of CD3⁺CD4⁺CD8^- and CD3⁺CD4^-CD8⁺ cells from CD3^-CD4^-CD8^- cells, the effect of argentogalactomannan was more potent. The efficiency of these compounds as agents improving the defense potential deserves special studies.

Keywords: argentogalactomannan;argento-poly-1-vinyl-1,2,4-triasole; nanocomposite; subpopulation composition; thymus.

MeSH terms

Lymphocyte Count
Metal Nanoparticles / adverse effects*
Nanocomposites / adverse effects*
Silver / adverse effects*
T-Lymphocyte Subsets / drug effects
Thymus Gland / drug effects
Thymus Gland / pathology*
Vaccines / adverse effects

Substances

Vaccines
Silver