Enhancer-Derived lncRNAs Regulate Genome Architecture: Fact or Fiction?

Stephanie Fanucchi; Musa M Mhlanga

doi:10.1016/j.tig.2017.03.004

Enhancer-Derived lncRNAs Regulate Genome Architecture: Fact or Fiction?

Trends Genet. 2017 Jun;33(6):375-377. doi: 10.1016/j.tig.2017.03.004. Epub 2017 Mar 27.

Authors

Stephanie Fanucchi¹, Musa M Mhlanga²

Affiliations

¹ Division of Chemical, Systems, and Synthetic Biology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Gene Expression and Biophysics Group, Biomedical Translational Research Initiative (BTRI), Council for Scientific and Industrial Research (CSIR) Biosciences, Pretoria, South Africa. Electronic address: parrucchiere@mhlangalab.org.
² Division of Chemical, Systems, and Synthetic Biology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Gene Expression and Biophysics Group, Biomedical Translational Research Initiative (BTRI), Council for Scientific and Industrial Research (CSIR) Biosciences, Pretoria, South Africa. Electronic address: yoda@mhlangalab.org.

PMID: 28359583
DOI: 10.1016/j.tig.2017.03.004

Abstract

How does the non-coding portion of the genome contribute to the regulation of genome architecture? A recent paper by Tan et al. focuses on the relationship between cis-acting complex-trait-associated lincRNAs and the formation of chromosomal contacts in topologically associating domains (TADs).

Publication types

Comment

MeSH terms

Chromosomes / genetics*
Enhancer Elements, Genetic*
Epigenesis, Genetic
Genome, Human
Genome-Wide Association Study
Humans
Promoter Regions, Genetic
RNA, Long Noncoding / genetics*
Regulatory Sequences, Nucleic Acid / genetics

Substances

RNA, Long Noncoding