Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine

Andy D Weyer; Sonya G Lehto

doi:10.3390/ph10020037

Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine

Pharmaceuticals (Basel). 2017 Mar 30;10(2):37. doi: 10.3390/ph10020037.

Authors

Andy D Weyer¹, Sonya G Lehto²

Affiliations

¹ Pacific University School of Physical Therapy, Hillsboro, OR 97123, USA. andy.weyer@pacificu.edu.
² One Amgen Center Dr, Thousand Oaks, CA 91320, USA. slehto@amgen.com.

Abstract

A review. Development of pharmaceutical antagonists of transient receptor potential melastatin 8 (TRPM8) have been pursued for the treatment of chronic pain and migraine. This review focuses on the current state of this progress.

Keywords: cold analgesia; cold hyperalgesia; mechanical hyperalgesia; menthol; migraine; pain; transient receptor potential melastatin 8 (TRPM*).

Publication types

Review