Mitochondrial type II NAD(P)H dehydrogenases in fungal cell death

A Pedro Gonçalves; Arnaldo Videira

doi:10.15698/mic2015.03.192

Mitochondrial type II NAD(P)H dehydrogenases in fungal cell death

Microb Cell. 2015 Mar 2;2(3):68-73. doi: 10.15698/mic2015.03.192.

Authors

A Pedro Gonçalves¹, Arnaldo Videira²

Affiliations

¹ ICBAS-Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal. ; IBMC-Instituto de Biologia Molecular e Celular - Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal. ; Current address: Plant and Microbial Biology Department, The University of California, Berkeley, CA 94720, USA.
² ICBAS-Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal. ; IBMC-Instituto de Biologia Molecular e Celular - Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal. ; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal.

Abstract

During aerobic respiration, cells produce energy through oxidative phosphorylation, which includes a specialized group of multi-subunit complexes in the inner mitochondrial membrane known as the electron transport chain. However, this canonical pathway is branched into single polypeptide alternative routes in some fungi, plants, protists and bacteria. They confer metabolic plasticity, allowing cells to adapt to different environmental conditions and stresses. Type II NAD(P)H dehydrogenases (also called alternative NAD(P)H dehydrogenases) are non-proton pumping enzymes that bypass complex I. Recent evidence points to the involvement of fungal alternative NAD(P)H dehydrogenases in the process of programmed cell death, in addition to their action as overflow systems upon oxidative stress. Consistent with this, alternative NAD(P)H dehydrogenases are phylogenetically related to cell death - promoting proteins of the apoptosis-inducing factor (AIF)-family.

Keywords: ROS; alternative NAD(P)H dehydrogenases; fungi; programmed cell death.

Publication types

Review

Grants and funding

We thank the SPELL website for providing access to the microarray datasets and for providing the query-driven search engine to get ranked co-regulators as used in our study. We further thank the providers of free software development tools (Code::Blocks, Bloodshed, Microsoft) and webserver tools (Apache Software Foundation, The PHP Group) which we used in this study. We thank Christopher Stratil for helpful comments on the manuscript.