Pediatric Non-Alcoholic Fatty Liver Disease

J Med Biochem. 2015 Jan;34(1):3-12. doi: 10.2478/jomb-2014-0059. Epub 2014 Oct 8.

Abstract

The rapidly increasing prevalence of childhood obesity and its associated co-morbidities such as hypertriglyceridemia, hyper-insulinemia, hypertension, early atherosclerosis, metabolic syndrome, and non-alcoholic fatty liver disease are major public health concerns in many countries. Therefore the trends in child and adolescent obesity should be closely monitored over time, as in the near future, we may anticipate a major increase of young adults with the stigmata of the metabolic syndrome, and of the related non-alcoholic fatty liver disease (NAFLD), that may lead to non-alcoholic steatohepatitis.

Naglo povećanje prevalence gojaznosti u detinjstvu i pratećih komorbiditeta kako što su hipertrigli-ceridemija, hiper-insulinemija, hipertenzija, rana ateroskleroza, metabolički sindrom, i ne-alkoholna masna jetra su glavni zdravstveni problemi u mnogim zemljama. To znači da trendove gojaznosti kod dece i omladine treba pratiti blagovremeno, s obzirom da se u bliskoj budućnosti očekuje povećana učestalost metaboličkog sindroma u ovoj populaciji, kao i pratećih oboljenja kao što je oboljenje ne-alkoholne masne jetre (NAFLD), koja može prouzrokovati ne-alkoholni steatohepatitis.

Keywords: NAFLD; non-alcoholic fatty liver disease; paediatric obesity; steatohepatitis.

Publication types

  • Review