To investigate the etiology and differential diagnoses of patients with systemic lupus erythematosus (SLE) and fever of unknown origin (FUO). From January 2012 to December 2014, a total of 928 SLE patients were admitted to Peking Union Medical College Hospital.Only 50 patients were combined with FUO (5.4%). The most common reason of fever was caused by infections(33 cases, 66.0%), including bacterial infection in 17 cases with 5 tuberculosis, viral infection in 11 cases, and fungal infection in 5 cases.The second reason offever was due to poor disease control or recurrence in 17 patients (34.0%). No fever was caused by malignant tumor.When clinical data was compared between 17 non-infected patients versus 33 infected patients, C reactive protein and procalcitonin in the infected group were significantly higher than those in the non-infected group.In SLE patients combined with FUO, infection is the most common etiology which is necessary to be paid attention to.
回顾性分析系统性红斑狼疮(SLE)合并不明原因发热(FUO)的病因，为SLE合并FUO的鉴别诊断提供帮助。2012年1月至2014年12月北京协和医院住院SLE患者928例，符合SLE合并FUO患者50例(5.4%)，单纯病情控制不佳或复发引起的发热17例(34.0%)；单纯感染引起发热33例(66.0%)，病原学检查提示细菌感染17例(其中结核分枝杆菌感染5例)，病毒感染11例，真菌感染5例；无恶性肿瘤引起发热。50例SLE合并FUO患者中，非感染者17例，感染者33例。感染者较非感染者C反应蛋白、降钙素原升高。SLE合并FUO以感染多见，临床应予重视。.
Keywords: Fever of unknown origin; Lupus erythematosus, systemic.