An uncommon case of arterial aneurysms association with high plasma levels of Matrix Metalloproteinase-9 and Neutrophil Gelatinase-Associated Lipocalin

Giovanni De Caridi; Mafalda Massara; Francesco Spinelli; Raffaele Grande; Lucia Butrico; Pierandrea Rende; Maurizio Amato; Rita Compagna; Bruno Amato; Stefano de Franciscis; Raffaele Serra

doi:10.1515/med-2015-0083

An uncommon case of arterial aneurysms association with high plasma levels of Matrix Metalloproteinase-9 and Neutrophil Gelatinase-Associated Lipocalin

Open Med (Wars). 2015 Dec 17;10(1):492-497. doi: 10.1515/med-2015-0083. eCollection 2015.

Authors

Affiliations

¹ Cardiovascular and Thoracic Department, University of Messina, Messina, Italy.
² Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro. Catanzaro, Italy.
³ Department of Health Sciences, University Magna Graecia of Catanzaro. Catanzaro, Italy.
⁴ Department of Clinical Medicine and Surgery, University Federico II of Naples. Naples, Italy ; Interuniversity Center of Phlebolymphology (CIFL). International Research and Educational Program in Clinical and Experimental Biotechnology. Headquarters: University Magna Graecia of Catanzaro, Catanzaro, Italy.
⁵ Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro. Catanzaro, Italy . Interuniversity Center of Phlebolymphology (CIFL). International Research and Educational Program in Clinical and Experimental Biotechnology. Headquarters: University Magna Graecia of Catanzaro, Catanzaro, Italy.
⁶ Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro. Catanzaro, Italy ; Interuniversity Center of Phlebolymphology (CIFL). International Research and Educational Program in Clinical and Experimental Biotechnology. Headquarters: University Magna Graecia of Catanzaro, Catanzaro, Italy.

Abstract

The association of an axillary artery aneurysm and an abdominal aortic aneurysm is extremely rare. In this study, we describe this association in a 69 year-old-man. We measured this patient's metalloproteinases (MMPs) and Neutrophil Gelatinase - Associated Lipocalin (NGAL) levels over a three years period before the abdominal aortic aneurysm rupture. We speculate that high serium levels of MMPs and NGAL may have a prognostic role and may predict aneurysm rupture in patients with an uncommon association of arterial aneurysms.

Keywords: Abdominal Aortic Aneurysm; Axillary Aneurysm; Matrix Metalloproteinase-9; Neutrophil Gelatinase – Associated Lipocalin.

Publication types

Case Reports