Scubatines A-F, new cytotoxic neo-clerodane diterpenoids from Scutellaria barbata D. Don

Fitoterapia. 2017 Jun:119:40-44. doi: 10.1016/j.fitote.2017.03.012. Epub 2017 Mar 27.

Abstract

Phytochemical investigation of the 70% acetone extract of the whole plant of Scutellaria barbata D. Don afforded six new neo-clerodane diterpenoids, scubatines A-F (1-6), and four known analogues (7-10). Their structures were elucidated on the basis of extensive spectroscopic analyses. Cytotoxic activity against the HL-60 and A549 cell lines was assessed for all isolated compounds. Compound 9 exhibited moderate activity against HL-60 with an IC50 value of 5.6μM. Compound 6 showed weak cytotoxic activity against A549 and HL-60 with IC50 values of 10.4 and 15.3μM, respectively.

Keywords: Cytotoxic activity; Lamiaceae; Scutellaria barbata D. Don; neo-Clerodane diterpenoids.

MeSH terms

  • A549 Cells
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Diterpenes, Clerodane / chemistry*
  • Diterpenes, Clerodane / isolation & purification
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Molecular Structure
  • Scutellaria / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes, Clerodane