Abstract
A new biphenyl-furocoumarin, named morescoumarin A (1), and a new prenylated flavanone, named morflavanone A (2) were isolated from the root bark of Morus alba L., together with four known compounds (3-6). Their structures were determined by extensive spectroscopic analyses and comparison with literature data. The cardioprotective effects of these compounds against doxorubicin-induced cell death were evaluated by MTT method.
Keywords:
Moraceae; Morus alba L; cardioprotective effect; phenolic constituents.
MeSH terms
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Animals
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Cardiotonic Agents / chemistry*
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Cardiotonic Agents / isolation & purification
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Cardiotonic Agents / pharmacology
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Cell Line
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Flavanones / chemistry*
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Flavanones / isolation & purification
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Flavanones / pharmacology
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Morus / chemistry*
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Myocytes, Cardiac / drug effects
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Phenols / chemistry*
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Phenols / isolation & purification
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Phenols / pharmacology
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Plant Bark / chemistry
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Plant Roots / chemistry*
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Prenylation
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Rats
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Spectrometry, Mass, Electrospray Ionization
Substances
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Cardiotonic Agents
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Flavanones
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Phenols