Near-Infrared Fluorescent Nanoprobes for in Vivo Optical Imaging

Chai-Hoon Quek; Kam W Leong

doi:10.3390/nano2020092

Near-Infrared Fluorescent Nanoprobes for in Vivo Optical Imaging

Nanomaterials (Basel). 2012 Mar 30;2(2):92-112. doi: 10.3390/nano2020092.

Authors

Chai-Hoon Quek¹, Kam W Leong^{2

3}

Affiliations

¹ Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA. cq4@duke.edu.
² Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA. kam.leong@duke.edu.
³ Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. kam.leong@duke.edu.

Abstract

Near-infrared (NIR) fluorescent probes offer advantages of high photon penetration, reduced light scattering and minimal autofluorescence from living tissues, rendering them valuable for noninvasive mapping of molecular events, assessment of therapeutic efficacy, and monitoring of disease progression in animal models. This review provides an overview of the recent development of the design and optical property of the different classes of NIR fluorescent nanoprobes associated with in vivo imaging applications.

Keywords: fluorescent dyes; in vivo imaging; nanoprobes; nanotechnology; near-infrared.

Publication types

Review

Grants and funding

R01 HL089764/HL/NHLBI NIH HHS/United States