Role of skeletal muscle glucocorticoid receptor in systemic energy homeostasis

Hirotoshi Tanaka; Noriaki Shimizu; Noritada Yoshikawa

doi:10.1016/j.yexcr.2017.03.049

Role of skeletal muscle glucocorticoid receptor in systemic energy homeostasis

Exp Cell Res. 2017 Nov 1;360(1):24-26. doi: 10.1016/j.yexcr.2017.03.049. Epub 2017 Mar 24.

Authors

Hirotoshi Tanaka¹, Noriaki Shimizu², Noritada Yoshikawa²

Affiliations

¹ Department of Rheumatology, Center for Antibody and Vaccine Therapy, IMSUT Hospital, Institute of Medical Science, University of Tokyo, Japan. Electronic address: hirotnk@ims.u-tokyo.ac.jp.
² Department of Rheumatology, Center for Antibody and Vaccine Therapy, IMSUT Hospital, Institute of Medical Science, University of Tokyo, Japan.

PMID: 28344055
DOI: 10.1016/j.yexcr.2017.03.049

Abstract

Glucocorticoids (GCs) affect nearly every organ and tissue in the body, regulating diverse physiologic processes including energy homeostasis. The metabolic mission of GCs is to supply enough glucose into the circulation to fuel the brain and ensure survival of the organism under conditions of acute stress or starvation. Recent studies have revealed that GCs, via orchestration between multiple organs, physiologically elicit fine tuning of systemic energy metabolism.

Keywords: Alanine; Amino acid; FGF21; Glucocorticoid; KLF15; Nuclear receptor; REDD1; mTOR.

Publication types

Review

MeSH terms

Animals
Energy Metabolism*
Homeostasis / physiology*
Humans
Muscle, Skeletal / physiology*
Receptors, Glucocorticoid / metabolism*

Substances

Receptors, Glucocorticoid