Role of HIF-1α signaling pathway in osteoarthritis: a systematic review
Rev Bras Reumatol Engl Ed. 2017 Mar-Apr;57(2):162-173.
doi: 10.1016/j.rbre.2016.07.008.
Epub 2016 Aug 5.
[Article in
English,
Portuguese]
Affiliations
- 1 Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Laboratorio de Líquido Sinovial, Mexico City, Mexico; Universidad Autónoma Metropolitana Iztapalapa, Programa de Doctorado de Ciencias Biológicas y de la Salud, Mexico City, Mexico. Electronic address: javier_astrofan@hotmail.com.
- 2 Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Laboratorio de Líquido Sinovial, Mexico City, Mexico.
- 3 Universidad Autónoma Metropolitana Iztapalapa, Programa de Doctorado de Ciencias Biológicas y de la Salud, Mexico City, Mexico.
- 4 Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Laboratorio de Líquido Sinovial, Mexico City, Mexico; Universidad Autónoma Metropolitana Iztapalapa, Programa de Doctorado de Ciencias Biológicas y de la Salud, Mexico City, Mexico.
Abstract
Osteoarthritis (OA) is the most common form of arthritis and is frequently diagnosed and managed in primary care; it is characterized by loss of articular hyaline cartilage, which is a unique connective tissue that physiologically lacks blood vessels. Articular cartilage survives in a microenvironment devoid of oxygen, which is regulated by hypoxia inducible factor (HIF-1α). HIF-1α is considered the main transcriptional regulator of cellular and developmental response to hypoxia. To date, the relevance of HIF-1α in the assessment of cartilage has increased since its participation is essential in the homeostasis of this tissue. Taking into account the new emerging insights of HIF-1α in the scientific literature in the last years, we focused the present review on the potential role of HIF-1α signaling pathway in OA development, especially in how some genetic factors may influence the maintenance or breakdown of articular cartilage.
Keywords:
Fator induzível por hipóxia 1-α; Genetic polymorphisms; HIF-1α signaling pathway; Hypoxia inducible factor-1α; Osteoarthritis; Osteoartrite; Polimorfismos genéticos; Via de sinalização do HIF-1α.
Copyright © 2016 Elsevier Editora Ltda. All rights reserved.
MeSH terms
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Cartilage, Articular / metabolism*
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Cartilage, Articular / pathology
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Gene Expression Regulation
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Humans
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Hypoxia-Inducible Factor 1 / physiology*
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Osteoarthritis / metabolism*
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Osteoarthritis / physiopathology
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Signal Transduction*
Substances
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Hypoxia-Inducible Factor 1